Gram-negative bacteremia upon hospital admission: when should Pseudomonas aeruginosa be suspected?

Journal Article (Journal Article)

BACKGROUND: Pseudomonas aeruginosa is an uncommon cause of community-acquired bacteremia among patients without severe immunodeficiency. Because tension exists between the need to limit unnecessary use of anti-pseudomonal agents and the need to avoid a delay in appropriate therapy, clinicians require better guidance regarding when to cover empirically for P. aeruginosa. We sought to determine the occurrence of and construct a model to predict P. aeruginosa bacteremia upon hospital admission. METHODS: A retrospective study was conducted in 4 tertiary care hospitals. Microbiology databases were searched to find all episodes of bacteremia caused by gram-negative rods (GNRs) 90 years, receipt of antimicrobial therapy within past 30 days, and presence of a central venous catheter or a urinary device. Among 250 patients without severe immunodeficiency, if no predictor variables existed, the likelihood of having P. aeruginosa bacteremia was 1:42. If >or= 2 predictors existed, the risk increased to nearly 1:3. CONCLUSIONS: P. aeruginosa bacteremia upon hospital admission in patients without severe immunodeficiency is rare. Among immunocompetent patients with suspected GNR bacteremia who have >or= 2 predictors, empirical anti-pseudomonal treatment is warranted.

Full Text

Duke Authors

Cited Authors

  • Schechner, V; Nobre, V; Kaye, KS; Leshno, M; Giladi, M; Rohner, P; Harbarth, S; Anderson, DJ; Karchmer, AW; Schwaber, MJ; Carmeli, Y

Published Date

  • March 1, 2009

Published In

Volume / Issue

  • 48 / 5

Start / End Page

  • 580 - 586

PubMed ID

  • 19191643

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/596709


  • eng

Conference Location

  • United States