Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.
Journal Article (Journal Article;Review)
Ca2+/calmodulin dependent protein kinase IV (CaMKIV) is a multifunctional, serine-threonine protein kinase that is activated in the presence of increased intracellular calcium (Ca2+). CaMKIV is a potent mediator of Ca2+ induced gene expression, primarily through its ability to phosphorylate and activate transcription factors such as CREB. CaMKIV-dependent activation of CREB is a key event in the expression of genes involved in the processes of T-cell activation and neuronal long term potentiation. The focus of this review is to describe the biochemical regulation of CaMKIV and examine how CaMKIV activates transcription in response to calcium in both cell and animal models.
- Anderson, KA; Kane, CD
- December 1998
- Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Volume / Issue
- 11 / 4
Start / End Page
- 331 - 343
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)