Skip to main content
Journal cover image

Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.

Publication ,  Journal Article
Anderson, KA; Kane, CD
Published in: Biometals
December 1998

Ca2+/calmodulin dependent protein kinase IV (CaMKIV) is a multifunctional, serine-threonine protein kinase that is activated in the presence of increased intracellular calcium (Ca2+). CaMKIV is a potent mediator of Ca2+ induced gene expression, primarily through its ability to phosphorylate and activate transcription factors such as CREB. CaMKIV-dependent activation of CREB is a key event in the expression of genes involved in the processes of T-cell activation and neuronal long term potentiation. The focus of this review is to describe the biochemical regulation of CaMKIV and examine how CaMKIV activates transcription in response to calcium in both cell and animal models.

Duke Scholars

Published In

Biometals

DOI

ISSN

0966-0844

Publication Date

December 1998

Volume

11

Issue

4

Start / End Page

331 / 343

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • T-Lymphocytes
  • Signal Transduction
  • Molecular Sequence Data
  • Humans
  • Gene Expression Regulation
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinase Type 4
  • Calcium
  • Biochemistry & Molecular Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Anderson, K. A., & Kane, C. D. (1998). Ca2+/calmodulin-dependent protein kinase IV and calcium signaling. Biometals, 11(4), 331–343. https://doi.org/10.1023/a:1009276932076
Anderson, K. A., and C. D. Kane. “Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.Biometals 11, no. 4 (December 1998): 331–43. https://doi.org/10.1023/a:1009276932076.
Anderson KA, Kane CD. Ca2+/calmodulin-dependent protein kinase IV and calcium signaling. Biometals. 1998 Dec;11(4):331–43.
Anderson, K. A., and C. D. Kane. “Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.Biometals, vol. 11, no. 4, Dec. 1998, pp. 331–43. Pubmed, doi:10.1023/a:1009276932076.
Anderson KA, Kane CD. Ca2+/calmodulin-dependent protein kinase IV and calcium signaling. Biometals. 1998 Dec;11(4):331–343.
Journal cover image

Published In

Biometals

DOI

ISSN

0966-0844

Publication Date

December 1998

Volume

11

Issue

4

Start / End Page

331 / 343

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • T-Lymphocytes
  • Signal Transduction
  • Molecular Sequence Data
  • Humans
  • Gene Expression Regulation
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinase Type 4
  • Calcium
  • Biochemistry & Molecular Biology