Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.
Publication
, Journal Article
Anderson, KA; Kane, CD
Published in: Biometals
December 1998
Ca2+/calmodulin dependent protein kinase IV (CaMKIV) is a multifunctional, serine-threonine protein kinase that is activated in the presence of increased intracellular calcium (Ca2+). CaMKIV is a potent mediator of Ca2+ induced gene expression, primarily through its ability to phosphorylate and activate transcription factors such as CREB. CaMKIV-dependent activation of CREB is a key event in the expression of genes involved in the processes of T-cell activation and neuronal long term potentiation. The focus of this review is to describe the biochemical regulation of CaMKIV and examine how CaMKIV activates transcription in response to calcium in both cell and animal models.
Duke Scholars
Published In
Biometals
DOI
ISSN
0966-0844
Publication Date
December 1998
Volume
11
Issue
4
Start / End Page
331 / 343
Location
Netherlands
Related Subject Headings
- Transcription, Genetic
- T-Lymphocytes
- Signal Transduction
- Molecular Sequence Data
- Humans
- Gene Expression Regulation
- Calcium-Calmodulin-Dependent Protein Kinases
- Calcium-Calmodulin-Dependent Protein Kinase Type 4
- Calcium
- Biochemistry & Molecular Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Anderson, K. A., & Kane, C. D. (1998). Ca2+/calmodulin-dependent protein kinase IV and calcium signaling. Biometals, 11(4), 331–343. https://doi.org/10.1023/a:1009276932076
Anderson, K. A., and C. D. Kane. “Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.” Biometals 11, no. 4 (December 1998): 331–43. https://doi.org/10.1023/a:1009276932076.
Anderson KA, Kane CD. Ca2+/calmodulin-dependent protein kinase IV and calcium signaling. Biometals. 1998 Dec;11(4):331–43.
Anderson, K. A., and C. D. Kane. “Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.” Biometals, vol. 11, no. 4, Dec. 1998, pp. 331–43. Pubmed, doi:10.1023/a:1009276932076.
Anderson KA, Kane CD. Ca2+/calmodulin-dependent protein kinase IV and calcium signaling. Biometals. 1998 Dec;11(4):331–343.
Published In
Biometals
DOI
ISSN
0966-0844
Publication Date
December 1998
Volume
11
Issue
4
Start / End Page
331 / 343
Location
Netherlands
Related Subject Headings
- Transcription, Genetic
- T-Lymphocytes
- Signal Transduction
- Molecular Sequence Data
- Humans
- Gene Expression Regulation
- Calcium-Calmodulin-Dependent Protein Kinases
- Calcium-Calmodulin-Dependent Protein Kinase Type 4
- Calcium
- Biochemistry & Molecular Biology