Ca2+/calmodulin-dependent protein kinase IV and calcium signaling.

Journal Article (Journal Article;Review)

Ca2+/calmodulin dependent protein kinase IV (CaMKIV) is a multifunctional, serine-threonine protein kinase that is activated in the presence of increased intracellular calcium (Ca2+). CaMKIV is a potent mediator of Ca2+ induced gene expression, primarily through its ability to phosphorylate and activate transcription factors such as CREB. CaMKIV-dependent activation of CREB is a key event in the expression of genes involved in the processes of T-cell activation and neuronal long term potentiation. The focus of this review is to describe the biochemical regulation of CaMKIV and examine how CaMKIV activates transcription in response to calcium in both cell and animal models.

Full Text

Duke Authors

Cited Authors

  • Anderson, KA; Kane, CD

Published Date

  • December 1998

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 331 - 343

PubMed ID

  • 10191497

International Standard Serial Number (ISSN)

  • 0966-0844

Digital Object Identifier (DOI)

  • 10.1023/a:1009276932076


  • eng

Conference Location

  • Netherlands