Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.

Published

Journal Article

Heme-regulated eIF2alpha kinase (HRI) is essential for regulating globin translation in iron deficiency and in beta-thalassemia. We investigated the role of heme-regulated eIF2alpha kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that HRI deficiency does not significantly affect red cell parameters of hemochromatosis (HFE(-)(/)(-)) mice. Importantly, heme-regulated eIF2alpha kinase deficiency exacerbates decreases in hepcidin expression and splenic macrophage iron in HFE(-)(/)(-) mice. Furthermore, the serum level of bone morphogenic protein 2, which positively regulates hepcidin, is reduced in heme-regulated eIF2alpha kinase deficiency, but not in HFE deficiency.

Full Text

Duke Authors

Cited Authors

  • Liu, S; Suragani, RNVS; Han, A; Zhao, W; Andrews, NC; Chen, J-J

Published Date

  • May 2008

Published In

Volume / Issue

  • 93 / 5

Start / End Page

  • 753 - 756

PubMed ID

  • 18367482

Pubmed Central ID

  • 18367482

Electronic International Standard Serial Number (EISSN)

  • 1592-8721

Digital Object Identifier (DOI)

  • 10.3324/haematol.12175

Language

  • eng

Conference Location

  • Italy