Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.
Journal Article (Journal Article)
Heme-regulated eIF2alpha kinase (HRI) is essential for regulating globin translation in iron deficiency and in beta-thalassemia. We investigated the role of heme-regulated eIF2alpha kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that HRI deficiency does not significantly affect red cell parameters of hemochromatosis (HFE(-)(/)(-)) mice. Importantly, heme-regulated eIF2alpha kinase deficiency exacerbates decreases in hepcidin expression and splenic macrophage iron in HFE(-)(/)(-) mice. Furthermore, the serum level of bone morphogenic protein 2, which positively regulates hepcidin, is reduced in heme-regulated eIF2alpha kinase deficiency, but not in HFE deficiency.
Full Text
Duke Authors
Cited Authors
- Liu, S; Suragani, RNVS; Han, A; Zhao, W; Andrews, NC; Chen, J-J
Published Date
- May 2008
Published In
Volume / Issue
- 93 / 5
Start / End Page
- 753 - 756
PubMed ID
- 18367482
Pubmed Central ID
- PMC3621076
Electronic International Standard Serial Number (EISSN)
- 1592-8721
Digital Object Identifier (DOI)
- 10.3324/haematol.12175
Language
- eng
Conference Location
- Italy