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Interleukin-6 induces hepcidin expression through STAT3.

Publication ,  Journal Article
Wrighting, DM; Andrews, NC
Published in: Blood
November 1, 2006

Iron homeostasis is maintained through meticulous regulation of circulating hepcidin levels. Hepcidin levels that are inappropriately low or high result in iron overload or iron deficiency, respectively. Although hypoxia, erythroid demand, iron, and inflammation are all known to influence hepcidin expression, the mechanisms responsible are not well defined. In this report we show that the inflammatory cytokine interleukin-6 (IL-6) directly regulates hepcidin through induction and subsequent promoter binding of signal transducer and activator of transcription 3 (STAT3). STAT3 is necessary and sufficient for the IL-6 responsiveness of the hepcidin promoter. Our findings provide a mechanism by which hepcidin can be regulated by inflammation or, in the absence of inflammatory stimuli, by alternative mechanisms leading to STAT3 activation.

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Published In

Blood

DOI

ISSN

0006-4971

Publication Date

November 1, 2006

Volume

108

Issue

9

Start / End Page

3204 / 3209

Location

United States

Related Subject Headings

  • STAT3 Transcription Factor
  • Protein Binding
  • Promoter Regions, Genetic
  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • Interleukin-6
  • Immunology
  • Humans
  • Hepcidins
  • DNA Primers
 

Citation

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Wrighting, D. M., & Andrews, N. C. (2006). Interleukin-6 induces hepcidin expression through STAT3. Blood, 108(9), 3204–3209. https://doi.org/10.1182/blood-2006-06-027631
Wrighting, Diedra M., and Nancy C. Andrews. “Interleukin-6 induces hepcidin expression through STAT3.Blood 108, no. 9 (November 1, 2006): 3204–9. https://doi.org/10.1182/blood-2006-06-027631.
Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006 Nov 1;108(9):3204–9.
Wrighting, Diedra M., and Nancy C. Andrews. “Interleukin-6 induces hepcidin expression through STAT3.Blood, vol. 108, no. 9, Nov. 2006, pp. 3204–09. Pubmed, doi:10.1182/blood-2006-06-027631.
Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006 Nov 1;108(9):3204–3209.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

November 1, 2006

Volume

108

Issue

9

Start / End Page

3204 / 3209

Location

United States

Related Subject Headings

  • STAT3 Transcription Factor
  • Protein Binding
  • Promoter Regions, Genetic
  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • Interleukin-6
  • Immunology
  • Humans
  • Hepcidins
  • DNA Primers