Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.

Published

Journal Article

Mammalian nonheme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1-null mice. We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron.

Full Text

Duke Authors

Cited Authors

  • Gunshin, H; Starr, CN; Direnzo, C; Fleming, MD; Jin, J; Greer, EL; Sellers, VM; Galica, SM; Andrews, NC

Published Date

  • October 15, 2005

Published In

Volume / Issue

  • 106 / 8

Start / End Page

  • 2879 - 2883

PubMed ID

  • 15961514

Pubmed Central ID

  • 15961514

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood-2005-02-0716

Language

  • eng

Conference Location

  • United States