Iron homeostasis and inherited iron overload disorders: an overview.

Journal Article (Journal Article;Review)

Iron is an ubiquitous metal of vital importance to the normal physiologic processes of many organisms. Recent discoveries of mutations in genes that lead to inherited iron overload diseases have advanced the understanding of iron homeostasis in humans. This article provides an overview of the human iron cycle, regulation of iron homeostasis, how perturbations in this homeostasis lead to iron overload disease in adults and children, and strategies for diagnosis of inherited iron overload.

Full Text

Duke Authors

Cited Authors

  • Heeney, MM; Andrews, NC

Published Date

  • December 2004

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 1379 - ix

PubMed ID

  • 15511621

International Standard Serial Number (ISSN)

  • 0889-8588

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2004.06.018


  • eng

Conference Location

  • United States