Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.

Published

Journal Article

The anemia of chronic disease is a prevalent, poorly understood condition that afflicts patients with a wide variety of diseases, including infections, malignancies, and rheumatologic disorders. It is characterized by a blunted erythropoietin response by erythroid precursors, decreased red blood cell survival, and a defect in iron absorption and macrophage iron retention, which interrupts iron delivery to erythroid precursor cells. We noted that patients with large hepatic adenomas had severe iron refractory anemia similar to that observed in anemia of chronic disease. This anemia resolved spontaneously after adenoma resection or liver transplantation. We investigated the role of the adenomas in the pathogenesis of the anemia and found that they produce inappropriately high levels of hepcidin mRNA. Hepcidin is a peptide hormone that has been implicated in controlling the release of iron from cells. We conclude that hepcidin plays a major, causative role in the anemia observed in our subgroup of patients with hepatic adenomas, and we speculate that it is important in the pathogenesis of the anemia of chronic disease in general.

Full Text

Duke Authors

Cited Authors

  • Weinstein, DA; Roy, CN; Fleming, MD; Loda, MF; Wolfsdorf, JI; Andrews, NC

Published Date

  • November 15, 2002

Published In

Volume / Issue

  • 100 / 10

Start / End Page

  • 3776 - 3781

PubMed ID

  • 12393428

Pubmed Central ID

  • 12393428

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood-2002-04-1260

Language

  • eng

Conference Location

  • United States