Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences.


Journal Article

Menkes disease and Wilson disease are human disorders of copper metabolism. It has recently been shown that both are due to mutations in P-type ATPase copper transport molecules. Related heavy metal transporting ATPases have been described in several strains of bacteria. In an effort to isolate other mammalian metal transporters, we screened a human small intestine library with probes homologous to conserved sequences in the known proteins. Two novel cDNAs were isolated, which encode new members of this family. Surprisingly, they were both of bacterial origin, most likely derived from E. coli sequences transduced during library construction.

Full Text

Duke Authors

Cited Authors

  • Trenor, C; Lin, W; Andrews, NC

Published Date

  • December 30, 1994

Published In

Volume / Issue

  • 205 / 3

Start / End Page

  • 1644 - 1650

PubMed ID

  • 7811248

Pubmed Central ID

  • 7811248

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1994.2856


  • eng

Conference Location

  • United States