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The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.

Publication ,  Journal Article
Andrews, NC; Kotkow, KJ; Ney, PA; Erdjument-Bromage, H; Tempst, P; Orkin, SH
Published in: Proc Natl Acad Sci U S A
December 15, 1993

Erythroid transcription factor NF-E2 is a tissue-restricted heterodimeric protein which recognizes an extended AP-1 motif [(T/C)TGCTGA(C/G)TCA(T/C)] found in the upstream locus control regions of the alpha- and beta-globin gene clusters. A cDNA clone encoding a cell-type-specific subunit of NF-E2, designated p45 NF-E2, has previously been characterized and shown to encode a basic-leucine zipper DNA-binding protein. Here we describe protein purification and cloning of cDNA that encodes the second basic-leucine zipper subunit of the native NF-E2 heterodimer. This polypeptide, designated p18, is widely expressed. It displays extensive homology to the v-maf oncogene product and a human retinal-specific protein, NRL. Unusual features in the basic region shared by v-Maf, NRL, and p18 place them in a distinct subfamily of AP-1-like proteins.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

December 15, 1993

Volume

90

Issue

24

Start / End Page

11488 / 11492

Location

United States

Related Subject Headings

  • Zinc Fingers
  • Viral Proteins
  • Tumor Cells, Cultured
  • Transfection
  • Transcription Factors
  • Sequence Homology, Amino Acid
  • Proto-Oncogene Proteins c-jun
  • Oncogenes
  • Oncogene Proteins, Viral
  • Oncogene Protein v-maf
 

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Andrews, N. C., Kotkow, K. J., Ney, P. A., Erdjument-Bromage, H., Tempst, P., & Orkin, S. H. (1993). The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A, 90(24), 11488–11492. https://doi.org/10.1073/pnas.90.24.11488
Andrews, N. C., K. J. Kotkow, P. A. Ney, H. Erdjument-Bromage, P. Tempst, and S. H. Orkin. “The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.Proc Natl Acad Sci U S A 90, no. 24 (December 15, 1993): 11488–92. https://doi.org/10.1073/pnas.90.24.11488.
Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488–92.
Andrews, N. C., et al. “The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.Proc Natl Acad Sci U S A, vol. 90, no. 24, Dec. 1993, pp. 11488–92. Pubmed, doi:10.1073/pnas.90.24.11488.
Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488–11492.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

December 15, 1993

Volume

90

Issue

24

Start / End Page

11488 / 11492

Location

United States

Related Subject Headings

  • Zinc Fingers
  • Viral Proteins
  • Tumor Cells, Cultured
  • Transfection
  • Transcription Factors
  • Sequence Homology, Amino Acid
  • Proto-Oncogene Proteins c-jun
  • Oncogenes
  • Oncogene Proteins, Viral
  • Oncogene Protein v-maf