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Multimodal treatment of ADHD in the MTA: an alternative outcome analysis.

Publication ,  Journal Article
Conners, CK; Epstein, JN; March, JS; Angold, A; Wells, KC; Klaric, J; Swanson, JM; Arnold, LE; Abikoff, HB; Elliott, GR; Greenhill, LL ...
Published in: J Am Acad Child Adolesc Psychiatry
February 2001

OBJECTIVE: To conduct a post hoc investigation of the utility of a single composite measure of treatment outcome for the NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention-Deficit/Hyperactivity Disorder (MTA) at 14 months postbaseline. BACKGROUND: Examination of multiple measures one at a time in the main MTA intent-to-treat outcome analyses failed to detect a statistically significant advantage of combined treatment (Comb) over medication management (MedMgt). A measure that increases power and precision using a single outcome score may be a useful alternative to multiple outcome measures. METHOD: Factor analysis of baseline scores yielded two "source factors" (parent and teacher) and one "instrument factor" (parent-child interactions). A composite score was created from the average of standardized parent and teacher measures. RESULTS: The composite was internally consistent (alpha = .83), reliable (test-retest over 3 months = 0.86), and correlated 0.61 with clinician global judgments. In an intent-to-treat analysis, Comb was statistically significantly better than all other treatments, with effect sizes ranging from small (0.28) versus MedMgt, to moderately large (0.70) versus a community comparison group. CONCLUSIONS: A composite of ADHD variables may be an important tool in future treatment trials with ADHD and may avoid some of the statistical limitations of multiple measures.

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Published In

J Am Acad Child Adolesc Psychiatry

DOI

ISSN

0890-8567

Publication Date

February 2001

Volume

40

Issue

2

Start / End Page

159 / 167

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Reproducibility of Results
  • Randomized Controlled Trials as Topic
  • Psychometrics
  • Humans
  • Factor Analysis, Statistical
  • Effect Modifier, Epidemiologic
  • Developmental & Child Psychology
  • Combined Modality Therapy
  • Child
 

Citation

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Conners, C. K., Epstein, J. N., March, J. S., Angold, A., Wells, K. C., Klaric, J., … Wigal, T. (2001). Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. J Am Acad Child Adolesc Psychiatry, 40(2), 159–167. https://doi.org/10.1097/00004583-200102000-00010
Conners, C. K., J. N. Epstein, J. S. March, A. Angold, K. C. Wells, J. Klaric, J. M. Swanson, et al. “Multimodal treatment of ADHD in the MTA: an alternative outcome analysis.J Am Acad Child Adolesc Psychiatry 40, no. 2 (February 2001): 159–67. https://doi.org/10.1097/00004583-200102000-00010.
Conners CK, Epstein JN, March JS, Angold A, Wells KC, Klaric J, et al. Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):159–67.
Conners, C. K., et al. “Multimodal treatment of ADHD in the MTA: an alternative outcome analysis.J Am Acad Child Adolesc Psychiatry, vol. 40, no. 2, Feb. 2001, pp. 159–67. Pubmed, doi:10.1097/00004583-200102000-00010.
Conners CK, Epstein JN, March JS, Angold A, Wells KC, Klaric J, Swanson JM, Arnold LE, Abikoff HB, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, Newcorn JH, Pelham WE, Severe JB, Vitiello B, Wigal T. Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):159–167.
Journal cover image

Published In

J Am Acad Child Adolesc Psychiatry

DOI

ISSN

0890-8567

Publication Date

February 2001

Volume

40

Issue

2

Start / End Page

159 / 167

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Reproducibility of Results
  • Randomized Controlled Trials as Topic
  • Psychometrics
  • Humans
  • Factor Analysis, Statistical
  • Effect Modifier, Epidemiologic
  • Developmental & Child Psychology
  • Combined Modality Therapy
  • Child