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Heparin-induced thrombocytopenia.

Publication ,  Journal Article
Arepally, GM; Ortel, TL
Published in: Annu Rev Med
2010

Heparin-induced thrombocytopenia (HIT) is an immune-mediated hypercoagulable disorder caused by antibodies to platelet factor 4 (PF4) and heparin. HIT develops in temporal association with heparin therapy and manifests either as an unexplained thrombocytopenia or thrombocytopenia complicated by thrombosis. The propensity for thrombosis distinguishes HIT from other common drug-induced thrombocytopenias. Diagnosing HIT in hospitalized patients is often challenging because of the frequency of heparin use, occurrence of thrombocytopenia from other causes, and development of asymptomatic PF4/heparin antibodies in patients treated with heparin. This review summarizes our current understanding of the pathogenesis, clinical features, diagnostic criteria, and management approaches in HIT.

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Published In

Annu Rev Med

DOI

EISSN

1545-326X

Publication Date

2010

Volume

61

Start / End Page

77 / 90

Location

United States

Related Subject Headings

  • Thrombocytopenia
  • Platelet Factor 4
  • Humans
  • Heparin
  • General & Internal Medicine
  • Anticoagulants
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
NLM
Arepally, G. M., & Ortel, T. L. (2010). Heparin-induced thrombocytopenia. Annu Rev Med, 61, 77–90. https://doi.org/10.1146/annurev.med.042808.171814
Arepally, Gowthami M., and Thomas L. Ortel. “Heparin-induced thrombocytopenia.Annu Rev Med 61 (2010): 77–90. https://doi.org/10.1146/annurev.med.042808.171814.
Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med. 2010;61:77–90.
Arepally, Gowthami M., and Thomas L. Ortel. “Heparin-induced thrombocytopenia.Annu Rev Med, vol. 61, 2010, pp. 77–90. Pubmed, doi:10.1146/annurev.med.042808.171814.
Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med. 2010;61:77–90.

Published In

Annu Rev Med

DOI

EISSN

1545-326X

Publication Date

2010

Volume

61

Start / End Page

77 / 90

Location

United States

Related Subject Headings

  • Thrombocytopenia
  • Platelet Factor 4
  • Humans
  • Heparin
  • General & Internal Medicine
  • Anticoagulants
  • 3202 Clinical sciences
  • 1103 Clinical Sciences