The relationship between slow photoresponse recovery rate and temporal resolution of vision.

Published

Journal Article

The rate at which photoreceptors recover from excitation is thought to be critical for setting the temporal resolution of vision. Indeed, mutations in RGS9 (regulator of G-protein signaling 9) and R9AP (RGS9 anchor protein) proteins mediating rapid photoresponse recovery impair patients' ability to see moving objects. In this study, we analyzed temporal properties of retinal sensitivity and spatiotemporal aspects of visual behavior in R9AP knock-out mice. Surprisingly, we have found that this knock-out does not affect dim-light vision mediated by rods acting as single-photon counters. Under these conditions, vision was also unaffected in mice overexpressing R9AP in rods, which causes accelerated photoresponse recovery. However, in brighter light, slow photoresponse recovery in rods and cones impaired visual responses to high temporal frequency stimuli, as reported for the daylight vision of human patients. Therefore, the speed of photoresponse recovery can affect temporal resolution and motion detection when photoreceptors integrate signals from multiple photons but not when they act as single-photon counters.

Full Text

Duke Authors

Cited Authors

  • Umino, Y; Herrmann, R; Chen, C-K; Barlow, RB; Arshavsky, VY; Solessio, E

Published Date

  • October 10, 2012

Published In

Volume / Issue

  • 32 / 41

Start / End Page

  • 14364 - 14373

PubMed ID

  • 23055507

Pubmed Central ID

  • 23055507

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.1296-12.2012

Language

  • eng

Conference Location

  • United States