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The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.

Publication ,  Journal Article
Tate, RJ; Lochhead, A; Brzeski, H; Arshavsky, V; Pyne, NJ
Published in: Cell Biochem Biophys
1998

The type 6 phosphodiesterase (PDE-6) from retinal rod photoreceptors is an alpha beta gamma 2 heterotetramer. The alpha- and beta-subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma-subunits (P gamma) serve as a protein inhibitor of the enzyme. P gamma is believed to be expressed only in photoreceptors. Using RT-PCR, we have amplified the complete coding sequence for P gamma from mouse lung RNA. The expression of P gamma in this tissue may be related to its ability to interact the type 5 phosphodiesterase (PDE-5), which is the predominant cGMP binding protein in lung. We therefore suggest that P gamma may have a wider signaling role in mammalian cells than previously appreciated.

Duke Scholars

Published In

Cell Biochem Biophys

DOI

ISSN

1085-9195

Publication Date

1998

Volume

29

Issue

1-2

Start / End Page

133 / 144

Location

United States

Related Subject Headings

  • Rod Cell Outer Segment
  • RNA, Messenger
  • Molecular Sequence Data
  • Mice
  • Lung
  • Enzyme Activation
  • Cyclic Nucleotide Phosphodiesterases, Type 6
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Cyclic AMP-Dependent Protein Kinases
  • Biochemistry & Molecular Biology
 

Citation

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Tate, R. J., Lochhead, A., Brzeski, H., Arshavsky, V., & Pyne, N. J. (1998). The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung. Cell Biochem Biophys, 29(1–2), 133–144. https://doi.org/10.1007/BF02737832
Tate, R. J., A. Lochhead, H. Brzeski, V. Arshavsky, and N. J. Pyne. “The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.Cell Biochem Biophys 29, no. 1–2 (1998): 133–44. https://doi.org/10.1007/BF02737832.
Tate RJ, Lochhead A, Brzeski H, Arshavsky V, Pyne NJ. The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung. Cell Biochem Biophys. 1998;29(1–2):133–44.
Tate, R. J., et al. “The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.Cell Biochem Biophys, vol. 29, no. 1–2, 1998, pp. 133–44. Pubmed, doi:10.1007/BF02737832.
Tate RJ, Lochhead A, Brzeski H, Arshavsky V, Pyne NJ. The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung. Cell Biochem Biophys. 1998;29(1–2):133–144.
Journal cover image

Published In

Cell Biochem Biophys

DOI

ISSN

1085-9195

Publication Date

1998

Volume

29

Issue

1-2

Start / End Page

133 / 144

Location

United States

Related Subject Headings

  • Rod Cell Outer Segment
  • RNA, Messenger
  • Molecular Sequence Data
  • Mice
  • Lung
  • Enzyme Activation
  • Cyclic Nucleotide Phosphodiesterases, Type 6
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Cyclic AMP-Dependent Protein Kinases
  • Biochemistry & Molecular Biology