The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.

Published

Journal Article

The type 6 phosphodiesterase (PDE-6) from retinal rod photoreceptors is an alpha beta gamma 2 heterotetramer. The alpha- and beta-subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma-subunits (P gamma) serve as a protein inhibitor of the enzyme. P gamma is believed to be expressed only in photoreceptors. Using RT-PCR, we have amplified the complete coding sequence for P gamma from mouse lung RNA. The expression of P gamma in this tissue may be related to its ability to interact the type 5 phosphodiesterase (PDE-5), which is the predominant cGMP binding protein in lung. We therefore suggest that P gamma may have a wider signaling role in mammalian cells than previously appreciated.

Full Text

Duke Authors

Cited Authors

  • Tate, RJ; Lochhead, A; Brzeski, H; Arshavsky, V; Pyne, NJ

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 29 / 1-2

Start / End Page

  • 133 - 144

PubMed ID

  • 9631242

Pubmed Central ID

  • 9631242

International Standard Serial Number (ISSN)

  • 1085-9195

Digital Object Identifier (DOI)

  • 10.1007/BF02737832

Language

  • eng

Conference Location

  • United States