Tissue-specific expression of kallikrein-related genes in the rat.

Published

Journal Article

Four distinct kallikrein-related mRNAs (PS, S1, S2, and S3), encoded by members of a multigene family, are selectively expressed in various combinations in several rat tissues. Although closely related along most of the mRNA sequence, the four mRNAs can be selectively detected with synthetic oligonucleotide probes complementary to highly variable mRNA subregions. PS mRNA, which encodes an enzyme with true kallikrein activity, is present at high levels in the submaxillary gland, pancreas, and kidney. S1 mRNA, which encodes an enzyme similar to the PS kallikrein, is detected only in the submaxillary gland and is present at one-fifth the PS mRNA level. S2 mRNA, which encodes the enzyme tonin, is present in the submaxillary gland at half the PS mRNA level and at a slightly higher level in the prostate. S3 mRNA, which encodes an enzyme very similar to tonin, is present in the submaxillary gland at one-tenth the PS mRNA level and in the prostate at about the same level as tonin mRNA.

Full Text

Duke Authors

Cited Authors

  • Ashley, PL; MacDonald, RJ

Published Date

  • August 13, 1985

Published In

Volume / Issue

  • 24 / 17

Start / End Page

  • 4520 - 4527

PubMed ID

  • 3851673

Pubmed Central ID

  • 3851673

International Standard Serial Number (ISSN)

  • 0006-2960

Digital Object Identifier (DOI)

  • 10.1021/bi00338a006

Language

  • eng

Conference Location

  • United States