Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.

Journal Article (Journal Article)

It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.

Full Text

Duke Authors

Cited Authors

  • Need, AC; Attix, DK; McEvoy, JM; Cirulli, ET; Linney, KN; Wagoner, AP; Gumbs, CE; Giegling, I; Möller, H-J; Francks, C; Muglia, P; Roses, A; Gibson, G; Weale, ME; Rujescu, D; Goldstein, DB

Published Date

  • July 5, 2008

Published In

Volume / Issue

  • 147B / 5

Start / End Page

  • 667 - 668

PubMed ID

  • 18205171

Electronic International Standard Serial Number (EISSN)

  • 1552-485X

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.30658


  • eng

Conference Location

  • United States