Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations.

Journal Article (Journal Article;Review;Systematic Review)

Kikuchi's disease, also known as histiocytic necrotizing lymphadenitis, is a systemic illness with classic clinical findings of cervical lymphadenopathy and fever. Diagnosis is confirmed by lymph node histology, which reveals paracortical foci of necrosis and a histiocytic infiltrate. Kikuchi's disease has been associated with a number of infections, but no single source has been identified. Diverse, often nonspecific, cutaneous findings have been described in up to 40% of cases. Description of the histopathologic findings of skin lesions is limited to single case reports and one case series. We describe a 24-year-old woman with fevers, lymphadenopathy, hepatic and hematologic abnormalities, and a skin eruption involving the face, neck, trunk, and extremities with characteristic lymph node and cutaneous histopathologic findings. We completed a systematic review of the clinical presentations and histopathology of Kikuchi's disease.

Full Text

Duke Authors

Cited Authors

  • Atwater, AR; Longley, BJ; Aughenbaugh, WD

Published Date

  • July 2008

Published In

Volume / Issue

  • 59 / 1

Start / End Page

  • 130 - 136

PubMed ID

  • 18462833

Pubmed Central ID

  • 18462833

Electronic International Standard Serial Number (EISSN)

  • 1097-6787

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2008.03.012


  • eng

Conference Location

  • United States