Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis.

Published

Journal Article

Transcranial magnetic stimulation (TMS) is a technology that allows for non-invasive modulation of the excitability and function of discrete brain cortical areas. TMS uses alternating magnetic fields to induce electric currents in cortical tissue. In psychiatry, TMS has been studied primarily as a potential treatment for major depression. Most studies indicate that slow-frequency repetitive TMS (rTMS) and higher frequency rTMS have antidepressant properties. A meta-analysis of controlled studies indicates that this effect is fairly robust from a statistical viewpoint. However, effect sizes are heterogeneous, and few studies have shown that rTMS results in substantial rates of clinical response or remission, and the durability of antidepressant effects is largely unknown. We review in detail rTMS studies in the treatment of depression, as well as summarize treatment studies of mania, obsessive-compulsive disorder, post-traumatic stress disorder, and schizophrenia. We also review the application of TMS in the study of the pathophysiology of psychiatric disorders and summarize studies of the safety of TMS in human subjects.

Full Text

Duke Authors

Cited Authors

  • Burt, T; Lisanby, SH; Sackeim, HA

Published Date

  • March 2002

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 73 - 103

PubMed ID

  • 12057034

Pubmed Central ID

  • 12057034

International Standard Serial Number (ISSN)

  • 1461-1457

Digital Object Identifier (DOI)

  • 10.1017/S1461145702002791

Language

  • eng

Conference Location

  • England