Catecholamine-secreting paraganglioma of the thoracic spinal column: report of an unusual case and review of the literature.

Journal Article (Journal Article;Review)

BACKGROUND AND IMPORTANCE: Paragangliomas are rare tumors of neuroendocrine origin that arise from paraganglionic tissue of the extrachromaffin cell system. These lesions may be seen at various sites along the neuraxis. Primary thoracic paragangliomas have rarely been reported in the literature, with secretory thoracic lesions being exceedingly rare as only 3 previous cases have been cited. CLINICAL PRESENTATION: A 49-year-old woman presented with episodes of hypertension, palpitations, and diaphoresis. Workup revealed positive urine catecholamines and a thoracic spine mass extending into the thoracic apex. Preoperative α-blockade with phenoxybenzamine was used followed by posterior decompression and tumor resection. Arthrodesis from C5 to T4 was subsequently performed, and the patient received postoperative radiation. CONCLUSION: Two years postoperatively, the patient has continued to have regression of her symptoms. We report a rare case of a catecholamine-secreting primary thoracic paraganglioma in a 49-year-old woman. These tumors should be treated carefully by the neurosurgeon with preoperative assistance from endocrinology for α-blockade, followed by gross total resection and postoperative radiation if residual tumor remains.

Full Text

Duke Authors

Cited Authors

  • Simpson, LN; Hughes, BD; Karikari, IO; Mehta, AI; Hodges, TR; Cummings, TJ; Bagley, CA

Published Date

  • April 2012

Published In

Volume / Issue

  • 70 / 4

Start / End Page

  • E1049 - E1052

PubMed ID

  • 21788916

Electronic International Standard Serial Number (EISSN)

  • 1524-4040

Digital Object Identifier (DOI)

  • 10.1227/NEU.0b013e31822e5aae


  • eng

Conference Location

  • United States