Direct, regioselective synthesis of 2,2-dimethyl-2H-chromenes. Total syntheses of octandrenolone and precocenes I and II

Journal Article

Herein is reported an efficient method for the synthesis of 2,2-dimethyl-2H-chromenes in a single step from the corresponding phenol and 3-methyl-2-butenal via microwave irradiation in CDCl3. This protocol features a mild reaction environment (neutral, no added catalyst) which yields regioselective formation of the chromene and displays tolerance toward acid- and base-sensitive protecting groups. © 2009 Elsevier Ltd. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Adler, MJ; Baldwin, SW

Published Date

  • 2009

Published In

Volume / Issue

  • 50 / 36

Start / End Page

  • 5075 - 5079

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/j.tetlet.2009.06.090