Visualizing receptor endocytosis and trafficking.

Journal Article

G-protein-coupled 7 transmembrane domain receptors (GPCR-7TMR) represent the largest class of membrane protein drug targets. They respond to a plethora of ligands ranging from small molecules to polypeptide hormones. Upon activation, almost all GPCR-7TMRs undergo desensitization followed by receptor internalization and resensitization. This cycle is crucially important for regulating the signal emanating from the receptor and is tightly linked to the receptor and/or the ligands studied. In this chapter, we describe some of the technical approaches that can be used to study GPCR internalization and trafficking.

Full Text

Duke Authors

Cited Authors

  • Salahpour, A; Barak, LS

Published Date

  • 2011

Published In

Volume / Issue

  • 756 /

Start / End Page

  • 311 - 323

PubMed ID

  • 21870235

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

Digital Object Identifier (DOI)

  • 10.1007/978-1-61779-160-4_18

Language

  • eng

Conference Location

  • United States