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Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.

Publication ,  Journal Article
Wilbanks, AM; Fralish, GB; Kirby, ML; Barak, LS; Li, Y-X; Caron, MG
Published in: Science
December 24, 2004

beta-arrestins are multifunctional proteins that act as scaffolds and transducers of intracellular signals from heptahelical transmembrane-spanning receptors (7TMR). Hedgehog (Hh) signaling, which uses the putative 7TMR, Smoothened, is established as a fundamental pathway in development, and unregulated Hh signaling is associated with certain malignancies. Here, we show that the functional knockdown of beta-arrestin 2 in zebrafish embryos recapitulates the many phenotypes of Hh pathway mutants. Expression of wild-type beta-arrestin 2, or constitutive activation of the Hh pathway downstream of Smoothened, rescues the phenotypes caused by beta-arrestin 2 deficiency. These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

December 24, 2004

Volume

306

Issue

5705

Start / End Page

2264 / 2267

Location

United States

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • Zebrafish Proteins
  • Zebrafish
  • Transcription Factors
  • Trans-Activators
  • Smoothened Receptor
  • Signal Transduction
  • Repressor Proteins
  • Receptors, G-Protein-Coupled
 

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Wilbanks, A. M., Fralish, G. B., Kirby, M. L., Barak, L. S., Li, Y.-X., & Caron, M. G. (2004). Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science, 306(5705), 2264–2267. https://doi.org/10.1126/science.1104193
Wilbanks, Alyson M., Gregory B. Fralish, Margaret L. Kirby, Larry S. Barak, Yin-Xiong Li, and Marc G. Caron. “Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.Science 306, no. 5705 (December 24, 2004): 2264–67. https://doi.org/10.1126/science.1104193.
Wilbanks AM, Fralish GB, Kirby ML, Barak LS, Li Y-X, Caron MG. Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science. 2004 Dec 24;306(5705):2264–7.
Wilbanks, Alyson M., et al. “Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.Science, vol. 306, no. 5705, Dec. 2004, pp. 2264–67. Pubmed, doi:10.1126/science.1104193.
Wilbanks AM, Fralish GB, Kirby ML, Barak LS, Li Y-X, Caron MG. Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science. 2004 Dec 24;306(5705):2264–2267.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

December 24, 2004

Volume

306

Issue

5705

Start / End Page

2264 / 2267

Location

United States

Related Subject Headings

  • beta-Arrestins
  • beta-Arrestin 2
  • Zebrafish Proteins
  • Zebrafish
  • Transcription Factors
  • Trans-Activators
  • Smoothened Receptor
  • Signal Transduction
  • Repressor Proteins
  • Receptors, G-Protein-Coupled