Pleiotropic role for GRKs and β-arrestins in receptor regulation

Published

Journal Article

G protein-coupled receptor kinases and arrestin proteins are well-characterized mediators of agonist-dependent G protein-coupled receptor desensitization. These proteins are now shown to play a dual role in receptor regulation by mediating both receptor uncoupling and sequestration, a process important for receptor resensitization. β-Arrestins bound to phosphorylated β2-adrenergic and angiotensin II type 1A receptors act as intracellular trafficking molecules specifically targeting these receptors for dynamin-dependent clathrin-coated vesicle-mediated sequestration.

Duke Authors

Cited Authors

  • Ferguson, SSG; Zhang, J; Barak, LS; Caron, MG

Published Date

  • August 1, 1997

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 145 - 151

International Standard Serial Number (ISSN)

  • 0886-1714

Citation Source

  • Scopus