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Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab.

Publication ,  Journal Article
Port, RE; Bernstein, LJ; Barboriak, DP; Xu, L; Roberts, TPL; van Bruggen, N
Published in: Magn Reson Med
August 2010

Dynamic contrast enhanced MRI contrast agent kinetics in malignant tumors are typically complex, requiring multicompartment tumor models for adequate description. For consistent comparisons among tumors or among successive studies of the same tumor, we propose to estimate the total contrast agent-accessible volume fraction of tumor, including blood plasma, v(pe), and an average transfer rate constant across all tumor compartments, K(trans.av), by fitting a three-compartment tumor model and then calculating the area under the tumor impulse-response function (= v(pe)) and the ratio area under the tumor impulse response function over mean residence time in tumor (= K(trans.av)). If the duration of dynamic contrast enhanced MRI was too short to extrapolate the tumor impulse-response function to infinity with any confidence, then conditional parameters v(pe)(*) and K(trans.av*) should be calculated from the available incomplete impulse response function. Median decreases of 33% were found for both v(pe)(*) and K(trans.av*) in glioblastoma patients (n = 16) 24 hours after the administration of bevacizumab (P < 0.001). Median total contrast-enhancing tumor volume was reduced by 18% (P < 0.0001). The combined changes of tumor volume, v(pe)(*), and K(trans.av*) suggest a reduction of true v(pe), possibly accompanied by a reduction of true K(trans.av). The proposed method provides estimates of a scale and a shape parameter to describe contrast agent kinetics of varying complexity in a uniform way.

Duke Scholars

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

August 2010

Volume

64

Issue

2

Start / End Page

408 / 417

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Models, Neurological
  • Middle Aged
  • Metabolic Clearance Rate
  • Male
  • Kinetics
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
 

Citation

APA
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ICMJE
MLA
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Port, R. E., Bernstein, L. J., Barboriak, D. P., Xu, L., Roberts, T. P. L., & van Bruggen, N. (2010). Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab. Magn Reson Med, 64(2), 408–417. https://doi.org/10.1002/mrm.22399
Port, Ruediger E., Lisa J. Bernstein, Daniel P. Barboriak, Lu Xu, Timothy P. L. Roberts, and Nicholas van Bruggen. “Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab.Magn Reson Med 64, no. 2 (August 2010): 408–17. https://doi.org/10.1002/mrm.22399.
Port RE, Bernstein LJ, Barboriak DP, Xu L, Roberts TPL, van Bruggen N. Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab. Magn Reson Med. 2010 Aug;64(2):408–17.
Port, Ruediger E., et al. “Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab.Magn Reson Med, vol. 64, no. 2, Aug. 2010, pp. 408–17. Pubmed, doi:10.1002/mrm.22399.
Port RE, Bernstein LJ, Barboriak DP, Xu L, Roberts TPL, van Bruggen N. Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab. Magn Reson Med. 2010 Aug;64(2):408–417.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

August 2010

Volume

64

Issue

2

Start / End Page

408 / 417

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Models, Neurological
  • Middle Aged
  • Metabolic Clearance Rate
  • Male
  • Kinetics
  • Image Interpretation, Computer-Assisted
  • Image Enhancement