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Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents.

Publication ,  Journal Article
Tunks, RD; Clowse, MEB; Miller, SG; Brancazio, LR; Barker, PCA
Published in: Am J Obstet Gynecol
January 2013

OBJECTIVE: The importance of maternal autoantibody levels in congenital heart block and elucidation of maternal factors that may reduce disease burden require further clarification. STUDY DESIGN: Pregnancies complicated by maternal anti-Ro antibodies from 2007 through 2011 were retrospectively reviewed. RESULTS: In all, 33 women were followed up throughout pregnancy. Semiquantitative maternal anti-La levels were significantly higher in pregnancies complicated by fetal heart block of any degree (median difference, 227.5; P = .04), but there was no difference in maternal anti-Ro levels. In all, 94% of fetuses maintained normal conduction when the mother was treated with hydroxychloroquine or daily prednisone therapy throughout pregnancy, compared to 59% in the untreated group (odds ratio, 0.1; P = .04). CONCLUSION: Pregnancies complicated by fetal heart block did not have higher levels of maternal anti-Ro antibodies. Maternal anti-La level may be a useful predictor of fetal heart block. Maternal treatment with either hydroxychloroquine or daily low-dose prednisone throughout pregnancy may provide a protective effect.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

January 2013

Volume

208

Issue

1

Start / End Page

64.e1 / 64.e7

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Pregnancy
  • Prednisone
  • Obstetrics & Reproductive Medicine
  • Maternal-Fetal Exchange
  • Hydroxychloroquine
  • Humans
  • Heart Block
  • Female
 

Citation

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Tunks, R. D., Clowse, M. E. B., Miller, S. G., Brancazio, L. R., & Barker, P. C. A. (2013). Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents. Am J Obstet Gynecol, 208(1), 64.e1-64.e7. https://doi.org/10.1016/j.ajog.2012.09.020
Tunks, Robert D., Megan E. B. Clowse, Stephen G. Miller, Leo R. Brancazio, and Piers C. A. Barker. “Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents.Am J Obstet Gynecol 208, no. 1 (January 2013): 64.e1-64.e7. https://doi.org/10.1016/j.ajog.2012.09.020.
Tunks RD, Clowse MEB, Miller SG, Brancazio LR, Barker PCA. Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents. Am J Obstet Gynecol. 2013 Jan;208(1):64.e1-64.e7.
Tunks, Robert D., et al. “Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents.Am J Obstet Gynecol, vol. 208, no. 1, Jan. 2013, pp. 64.e1-64.e7. Pubmed, doi:10.1016/j.ajog.2012.09.020.
Tunks RD, Clowse MEB, Miller SG, Brancazio LR, Barker PCA. Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents. Am J Obstet Gynecol. 2013 Jan;208(1):64.e1-64.e7.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

January 2013

Volume

208

Issue

1

Start / End Page

64.e1 / 64.e7

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Pregnancy
  • Prednisone
  • Obstetrics & Reproductive Medicine
  • Maternal-Fetal Exchange
  • Hydroxychloroquine
  • Humans
  • Heart Block
  • Female