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Effect of varying contrast material iodine concentration and injection technique on the conspicuity of hepatocellular carcinoma during 64-section MDCT of patients with cirrhosis.

Publication ,  Journal Article
Guerrisi, A; Marin, D; Nelson, RC; De Filippis, G; Di Martino, M; Barnhart, H; Masciangelo, R; Guerrisi, I; Passariello, R; Catalano, C
Published in: Br J Radiol
August 2011

OBJECTIVES: The aim of this study was to compare the intraindividual effects of contrast material with two different iodine concentrations on the conspicuity of hepatocellular carcinoma (HCC) and vascular and hepatic contrast enhancement during multiphasic, 64-section multidetector row CT (MDCT) in patients with cirrhosis using two contrast medium injection techniques. METHODS: Patients were randomly assigned to one of two groups with an equal iodine dose but different contrast material injection techniques: scheme A, fixed injection duration (25 s), and scheme B, fixed injection flow rate (4 ml s(-1)). For each group, patients were randomised to receive both moderate-concentration contrast medium (MCCM) and high-concentration contrast medium (HCCM) during two CT examinations within 3 months. Enhancement of the aorta, liver and portal vein and the tumour-to-liver contrast-to-noise ratio (CNR) were compared between MCCM and HCCM. RESULTS: 30 patients (mean age 59 years; range 45-80 years; 16 patients in scheme A and 14 in scheme B) with a total of 31 confirmed HCC nodules were prospectively enrolled. For scheme B, the mean contrast enhancement of the aorta and tumour-to-liver CNR were significantly higher with HCCM than with MCCM during the hepatic arterial phase (+350.5 HU vs +301.1 HU, p = 0.001, and +7.5 HU vs +5.5 HU, p = 0.004). For both groups, there was no significant difference between MCCM and HCCM for all other comparisons. CONCLUSION: For a constant injection flow rate, HCCM significantly improves the conspicuity of HCC lesions and aortic enhancement during the hepatic arterial phase on 64-section MDCT in patients with cirrhosis.

Duke Scholars

Published In

Br J Radiol

DOI

EISSN

1748-880X

Publication Date

August 2011

Volume

84

Issue

1004

Start / End Page

698 / 708

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Prospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Liver Cirrhosis
  • Iodine
  • Injections, Intravenous
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Guerrisi, A., Marin, D., Nelson, R. C., De Filippis, G., Di Martino, M., Barnhart, H., … Catalano, C. (2011). Effect of varying contrast material iodine concentration and injection technique on the conspicuity of hepatocellular carcinoma during 64-section MDCT of patients with cirrhosis. Br J Radiol, 84(1004), 698–708. https://doi.org/10.1259/bjr/21539234
Guerrisi, A., D. Marin, R. C. Nelson, G. De Filippis, M. Di Martino, H. Barnhart, R. Masciangelo, I. Guerrisi, R. Passariello, and C. Catalano. “Effect of varying contrast material iodine concentration and injection technique on the conspicuity of hepatocellular carcinoma during 64-section MDCT of patients with cirrhosis.Br J Radiol 84, no. 1004 (August 2011): 698–708. https://doi.org/10.1259/bjr/21539234.
Guerrisi A, Marin D, Nelson RC, De Filippis G, Di Martino M, Barnhart H, et al. Effect of varying contrast material iodine concentration and injection technique on the conspicuity of hepatocellular carcinoma during 64-section MDCT of patients with cirrhosis. Br J Radiol. 2011 Aug;84(1004):698–708.
Guerrisi, A., et al. “Effect of varying contrast material iodine concentration and injection technique on the conspicuity of hepatocellular carcinoma during 64-section MDCT of patients with cirrhosis.Br J Radiol, vol. 84, no. 1004, Aug. 2011, pp. 698–708. Pubmed, doi:10.1259/bjr/21539234.
Guerrisi A, Marin D, Nelson RC, De Filippis G, Di Martino M, Barnhart H, Masciangelo R, Guerrisi I, Passariello R, Catalano C. Effect of varying contrast material iodine concentration and injection technique on the conspicuity of hepatocellular carcinoma during 64-section MDCT of patients with cirrhosis. Br J Radiol. 2011 Aug;84(1004):698–708.

Published In

Br J Radiol

DOI

EISSN

1748-880X

Publication Date

August 2011

Volume

84

Issue

1004

Start / End Page

698 / 708

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Prospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Liver Cirrhosis
  • Iodine
  • Injections, Intravenous
  • Humans