Leptospirosis among hospitalized febrile patients in northern Tanzania.

Journal Article (Journal Article)

We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal MAT titer ≥ 800; and exposure to pathogenic leptospires as titer ≥ 100. Among 870 patients enrolled in the study, 453 (52.1%) had paired sera available, and 40 (8.8%) of these met the definition for confirmed leptospirosis. Of 832 patients with ≥ 1 serum sample available, 30 (3.6%) had probable leptospirosis and an additional 277 (33.3%) had evidence of exposure to pathogenic leptospires. Among those with leptospirosis the most common clinical diagnoses were malaria in 31 (44.3%) and pneumonia in 18 (25.7%). Leptospirosis was associated with living in a rural area (odds ratio [OR] 3.4, P < 0.001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic.

Full Text

Duke Authors

Cited Authors

  • Biggs, HM; Bui, DM; Galloway, RL; Stoddard, RA; Shadomy, SV; Morrissey, AB; Bartlett, JA; Onyango, JJ; Maro, VP; Kinabo, GD; Saganda, W; Crump, JA

Published Date

  • August 2011

Published In

Volume / Issue

  • 85 / 2

Start / End Page

  • 275 - 281

PubMed ID

  • 21813847

Pubmed Central ID

  • PMC3144825

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.2011.11-0176


  • eng

Conference Location

  • United States