Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview.


Journal Article (Review)

BACKGROUND: Many trials of antiretroviral therapy in treatment-naïve subjects have investigated the relative efficacy of the third drug in a treatment regimen. However, the nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) components may also affect efficacy. METHOD: A systematic overview of clinical trials studying initial treatment in naïve subjects receiving efavirenz-containing regimens and providing week 48 time to loss of virologic response (TLOVR) results was undertaken to compare results with different NRTI combinations. RESULTS: Seven trials studying 3,807 subjects were identified that met the inclusion criteria. Baseline characteristics were similar across studies. Using the week 48 TLOVR results as the primary method of comparison, combinations of tenofovir and lamivudine or emtricitabine appeared to provide improved virologic responses. Similar results were obtained when the proportions of subjects with plasma HIV RNA levels <50 copies/mL were examined.

Full Text

Duke Authors

Cited Authors

  • Bartlett, JA; Chen, S-S; Quinn, JB

Published Date

  • July 2007

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 221 - 226

PubMed ID

  • 17720662

Pubmed Central ID

  • 17720662

International Standard Serial Number (ISSN)

  • 1528-4336

Digital Object Identifier (DOI)

  • 10.1310/hct0804-221


  • eng

Conference Location

  • England