A randomized study of antiviral medication switch at lower- versus higher-switch thresholds: AIDS Clinical Trials Group Study A5115.

Journal Article (Journal Article)

BACKGROUND: Clinical stability has been observed with continued antiretroviral therapy (ART) in the setting of partial virological suppression. The optimal time to switch treatment in patients with low but detectable HIV-1 RNA is not known. METHODS: Subjects on stable ART with HIV-1 RNA 200-10,000 copies/ml were randomized to an immediate treatment switch, or to a delayed switch when HIV-1 RNA increased to > or = 10,000 copies/ml or CD4+ T-cell count decreased by 20%. The primary outcome measures were immune activation (proportion of CD8+ T-cells expressing CD38 at week 48) and evolution of genotypic drug resistance. RESULTS: The study failed to fully accrue the originally planned 108 subjects. Only 47 subjects were randomized to immediate- or delayed-switch arms. Of the subjects in the delayed-switch arm, 10/23 (43%) met the criteria for ART switch during the study (median follow-up 82 weeks). After 48 weeks of observation, the level of immune activation was comparable in the two arms. New resistance mutations were observed in 3/17 and 8/19 subjects in the immediate- and delayed-switch groups, respectively. The loss of future treatment options, however, was comparable in the delayed- and immediate-switch groups. CONCLUSIONS: Individuals with partial viral suppression tend to remain immunologically stable, however, the accumulation of drug resistance mutations is an ongoing risk. Delayed switch in ART may be a reasonable short-term strategy for individuals with very limited treatment options.

Full Text

Duke Authors

Cited Authors

  • Riddler, SA; Jiang, H; Tenorio, A; Huang, H; Kuritzkes, DR; Acosta, EP; Landay, A; Bastow, B; Haas, DW; Tashima, KT; Jain, MK; Deeks, SG; Bartlett, JA

Published Date

  • 2007

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 531 - 541

PubMed ID

  • 17668562

International Standard Serial Number (ISSN)

  • 1359-6535

Digital Object Identifier (DOI)

  • 10.1177/135965350701200415


  • eng

Conference Location

  • England