Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration.

Journal Article (Journal Article)

Associations have been reported between an MDR1 variant and responses to nonnucleoside reverse-transcriptase inhibitors. We explored associations between MDR1, CYP2B6, and CYP3A polymorphisms and nevirapine hepatotoxicity. Among participants in a randomized study in South Africa (FTC-302), MDR1 3435C-->T was significantly associated with decreased risk of hepatotoxicity (risk ratio, 0.30; P=.016).

Full Text

Duke Authors

Cited Authors

  • Haas, DW; Bartlett, JA; Andersen, JW; Sanne, I; Wilkinson, GR; Hinkle, J; Rousseau, F; Ingram, CD; Shaw, A; Lederman, MM; Kim, RB; Adult AIDS Clinical Trials Group,

Published Date

  • September 15, 2006

Published In

Volume / Issue

  • 43 / 6

Start / End Page

  • 783 - 786

PubMed ID

  • 16912957

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/507097


  • eng

Conference Location

  • United States