Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.

Journal Article (Journal Article)

We report the emergence of drug-resistant viral mutations in chronically HIV-infected individual undergoing structured treatment interruptions (STI). THe protease mutations K101E and K103N were detected at the end of the second or third STI. We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.

Full Text

Duke Authors

Cited Authors

  • Schweighardt, B; Ortiz, GM; Grant, RM; Wellons, M; Miralles, GD; Kostrikis, LG; Bartlett, JA; Nixon, DF

Published Date

  • November 22, 2002

Published In

Volume / Issue

  • 16 / 17

Start / End Page

  • 2342 - 2344

PubMed ID

  • 12441810

International Standard Serial Number (ISSN)

  • 0269-9370

Digital Object Identifier (DOI)

  • 10.1097/00002030-200211220-00018


  • eng

Conference Location

  • England