Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.
Publication
, Journal Article
Schweighardt, B; Ortiz, GM; Grant, RM; Wellons, M; Miralles, GD; Kostrikis, LG; Bartlett, JA; Nixon, DF
Published in: AIDS
November 22, 2002
We report the emergence of drug-resistant viral mutations in chronically HIV-infected individual undergoing structured treatment interruptions (STI). THe protease mutations K101E and K103N were detected at the end of the second or third STI. We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.
Duke Scholars
Published In
AIDS
DOI
ISSN
0269-9370
Publication Date
November 22, 2002
Volume
16
Issue
17
Start / End Page
2342 / 2344
Location
England
Related Subject Headings
- Virology
- RNA, Viral
- Mutation
- Humans
- HIV-1
- HIV Infections
- Drug Therapy, Combination
- Drug Resistance, Viral
- Drug Administration Schedule
- Anti-HIV Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Schweighardt, B., Ortiz, G. M., Grant, R. M., Wellons, M., Miralles, G. D., Kostrikis, L. G., … Nixon, D. F. (2002). Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions. AIDS, 16(17), 2342–2344. https://doi.org/10.1097/00002030-200211220-00018
Schweighardt, Becky, Gabriel M. Ortiz, Robert M. Grant, Melissa Wellons, G Diego Miralles, Leondios G. Kostrikis, John A. Bartlett, and Douglas F. Nixon. “Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.” AIDS 16, no. 17 (November 22, 2002): 2342–44. https://doi.org/10.1097/00002030-200211220-00018.
Schweighardt B, Ortiz GM, Grant RM, Wellons M, Miralles GD, Kostrikis LG, et al. Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions. AIDS. 2002 Nov 22;16(17):2342–4.
Schweighardt, Becky, et al. “Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.” AIDS, vol. 16, no. 17, Nov. 2002, pp. 2342–44. Pubmed, doi:10.1097/00002030-200211220-00018.
Schweighardt B, Ortiz GM, Grant RM, Wellons M, Miralles GD, Kostrikis LG, Bartlett JA, Nixon DF. Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions. AIDS. 2002 Nov 22;16(17):2342–2344.
Published In
AIDS
DOI
ISSN
0269-9370
Publication Date
November 22, 2002
Volume
16
Issue
17
Start / End Page
2342 / 2344
Location
England
Related Subject Headings
- Virology
- RNA, Viral
- Mutation
- Humans
- HIV-1
- HIV Infections
- Drug Therapy, Combination
- Drug Resistance, Viral
- Drug Administration Schedule
- Anti-HIV Agents