A placebo-controlled trial of ranitidine in patients with early human immunodeficiency virus infection.

Journal Article (Clinical Trial;Journal Article)

Previous uncontrolled reports have suggested that H2-antagonists may possess immunomodulatory activity in human immunodeficiency virus (HIV)-infected patients. Such trials reported improvements in HIV-related symptoms, increased absolute CD4 cell numbers, and improvements in other measures of host immunity. The present trial was a randomized, placebo-controlled, double-blind trial of ranitidine 300 mg (orally twice daily) in subjects with early HIV infection (absolute CD4 cells, 400-700/mm3). Eighty-one subjects entered the trial and 73 completed 16 weeks on study medications. There were no significant differences in the time-weighted average change from baseline between the 2 treatment groups in absolute CD4 cell number, plasma HIV RNA level, or most other surrogate markers of HIV infection. Serum beta2-microglobulin levels were significantly lower in placebo than ranitidine recipients. Ranitidine should not be recommended for the treatment of HIV-infected patients unless it is used for established indications.

Full Text

Duke Authors

Cited Authors

  • Bartlett, JA; Berry, PS; Bockman, KW; Stein, A; Johnson, J; Graham, S; Quinn, J; DeMasi, R; Alexander, WJ

Published Date

  • January 1998

Published In

Volume / Issue

  • 177 / 1

Start / End Page

  • 231 - 234

PubMed ID

  • 9419196

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/517361


  • eng

Conference Location

  • United States