Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes.

Journal Article (Clinical Trial;Journal Article)

Initiation of antiretroviral monotherapy early in the course of infection with human immunodeficiency virus may result in a temporary slowing in the rate of disease progression; however, little is known about the virologic effects of early therapy. Virus load was measured in peripheral blood and lymph nodes from 16 antiretroviral-naive patients with a mean CD4 T lymphocyte count of 659 cells/microliter at baseline and after 8 weeks of either no treatment or zidovudine therapy. CD4 T lymphocyte counts and all virologic parameters examined remained unchanged regardless of zidovudine treatment status. Histopathology and virus distribution within lymph nodes remained constant between baseline and week 8 in each patient, indicating that the virologic and histologic parameters examined in a single lymph node are representative of a systemic process. Early antiretroviral monotherapy with zidovudine had no effect on virologic parameters in this group of patients with relatively high CD4 T lymphocyte counts and low measures of virus load at baseline.

Full Text

Duke Authors

Cited Authors

  • Cohen, OJ; Pantaleo, G; Holodniy, M; Fox, CH; Orenstein, JM; Schnittman, S; Niu, M; Graziosi, C; Pavlakis, GN; Lalezari, J; Bartlett, JA; Steigbigel, RT; Cohn, J; Novak, R; McMahon, D; Bilello, J; Fauci, AS

Published Date

  • April 1996

Published In

Volume / Issue

  • 173 / 4

Start / End Page

  • 849 - 856

PubMed ID

  • 8603962

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/173.4.849


  • eng

Conference Location

  • United States