Skip to main content

Clinical review: oxygen as a signaling molecule.

Publication ,  Journal Article
Bartz, RR; Piantadosi, CA
Published in: Crit Care
2010

Molecular oxygen is obviously essential for conserving energy in a form useable for aerobic life; however, its utilization comes at a cost--the production of reactive oxygen species (ROS). ROS can be highly damaging to a range of biological macromolecules, and in the past the overproduction of these short-lived molecules in a variety of disease states was thought to be exclusively toxic to cells and tissues such as the lung. Recent basic research, however, has indicated that ROS production--in particular, the production of hydrogen peroxide--plays an important role in both intracellular and extracellular signal transduction that involves diverse functions from vascular health to host defense. The present review summarizes oxygen's capacity, acting through its reactive intermediates, to recruit the enzymatic antioxidant defenses, to stimulate cell repair processes, and to mitigate cellular damage.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Crit Care

DOI

EISSN

1466-609X

Publication Date

2010

Volume

14

Issue

5

Start / End Page

234

Location

England

Related Subject Headings

  • Signal Transduction
  • Reactive Oxygen Species
  • Oxygen
  • Oxidative Stress
  • Humans
  • Emergency & Critical Care Medicine
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bartz, R. R., & Piantadosi, C. A. (2010). Clinical review: oxygen as a signaling molecule. Crit Care, 14(5), 234. https://doi.org/10.1186/cc9185
Bartz, Raquel R., and Claude A. Piantadosi. “Clinical review: oxygen as a signaling molecule.Crit Care 14, no. 5 (2010): 234. https://doi.org/10.1186/cc9185.
Bartz RR, Piantadosi CA. Clinical review: oxygen as a signaling molecule. Crit Care. 2010;14(5):234.
Bartz, Raquel R., and Claude A. Piantadosi. “Clinical review: oxygen as a signaling molecule.Crit Care, vol. 14, no. 5, 2010, p. 234. Pubmed, doi:10.1186/cc9185.
Bartz RR, Piantadosi CA. Clinical review: oxygen as a signaling molecule. Crit Care. 2010;14(5):234.

Published In

Crit Care

DOI

EISSN

1466-609X

Publication Date

2010

Volume

14

Issue

5

Start / End Page

234

Location

England

Related Subject Headings

  • Signal Transduction
  • Reactive Oxygen Species
  • Oxygen
  • Oxidative Stress
  • Humans
  • Emergency & Critical Care Medicine
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences