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Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.

Publication ,  Journal Article
Batinić-Haberle, I; Rebouças, JS; Spasojević, I
Published in: Antioxid Redox Signal
September 15, 2010

Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia-reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, natural and synthetic antioxidants have been actively sought. Superoxide dismutase is a first line of defense against oxidative stress under physiological and pathological conditions. Therefore, the development of therapeutics aimed at mimicking superoxide dismutase was a natural maneuver. Metalloporphyrins, as well as Mn cyclic polyamines, Mn salen derivatives and nitroxides were all originally developed as SOD mimics. The same thermodynamic and electrostatic properties that make them potent SOD mimics may allow them to reduce other reactive species such as peroxynitrite, peroxynitrite-derived CO(3)(*-), peroxyl radical, and less efficiently H(2)O(2). By doing so SOD mimics can decrease both primary and secondary oxidative events, the latter arising from the inhibition of cellular transcriptional activity. To better judge the therapeutic potential and the advantage of one over the other type of compound, comparative studies of different classes of drugs in the same cellular and/or animal models are needed. We here provide a comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds.

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Published In

Antioxid Redox Signal

DOI

EISSN

1557-7716

Publication Date

September 15, 2010

Volume

13

Issue

6

Start / End Page

877 / 918

Location

United States

Related Subject Headings

  • Superoxide Dismutase
  • Porphyrins
  • Polyamines
  • Organometallic Compounds
  • Manganese
  • Humans
  • Biomimetic Materials
  • Biochemistry & Molecular Biology
  • Animals
  • 3205 Medical biochemistry and metabolomics
 

Citation

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Batinić-Haberle, I., Rebouças, J. S., & Spasojević, I. (2010). Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal, 13(6), 877–918. https://doi.org/10.1089/ars.2009.2876
Batinić-Haberle, Ines, Júlio S. Rebouças, and Ivan Spasojević. “Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.Antioxid Redox Signal 13, no. 6 (September 15, 2010): 877–918. https://doi.org/10.1089/ars.2009.2876.
Batinić-Haberle I, Rebouças JS, Spasojević I. Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal. 2010 Sep 15;13(6):877–918.
Batinić-Haberle, Ines, et al. “Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.Antioxid Redox Signal, vol. 13, no. 6, Sept. 2010, pp. 877–918. Pubmed, doi:10.1089/ars.2009.2876.
Batinić-Haberle I, Rebouças JS, Spasojević I. Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal. 2010 Sep 15;13(6):877–918.
Journal cover image

Published In

Antioxid Redox Signal

DOI

EISSN

1557-7716

Publication Date

September 15, 2010

Volume

13

Issue

6

Start / End Page

877 / 918

Location

United States

Related Subject Headings

  • Superoxide Dismutase
  • Porphyrins
  • Polyamines
  • Organometallic Compounds
  • Manganese
  • Humans
  • Biomimetic Materials
  • Biochemistry & Molecular Biology
  • Animals
  • 3205 Medical biochemistry and metabolomics