Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution.

Journal Article (Journal Article)

We evaluate herein the impact of positive charge distribution on the in vitro and in vivo properties of Mn porphyrins as redox modulators possessing the same overall 5+ charge and of minimal stericity demand: Mn(III) meso-tetrakis(trimethylanilinium-4-yl)porphyrin (MnTTriMAP(5+)), Mn(III) meso-tetrakis(N,N'-dimethylpyrazolium-4-yl)porphyrin (MnTDM-4-PzP(5+)), Mn(III) meso-tetrakis(N,N'-dimethylimidazolium-2-yl)porphyrin (MnTDM-2-ImP(5+)), and the ortho and para methylpyridinium complexes Mn(III) meso-tetrakis(N-methylpyridinium-4-yl)porphyrin (MnTM-4-PyP(5+)) and Mn(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin (MnTM-2-PyP(5+)). Both Mn(III)/Mn(II) reduction potential and SOD activity within the series follow the order: MnTTriMAP(5+)

Full Text

Duke Authors

Cited Authors

  • Rebouças, JS; Spasojević, I; Tjahjono, DH; Richaud, A; Méndez, F; Benov, L; Batinić-Haberle, I

Published Date

  • March 7, 2008

Published In

Start / End Page

  • 1233 - 1242

PubMed ID

  • 18283384

International Standard Serial Number (ISSN)

  • 1477-9226

Digital Object Identifier (DOI)

  • 10.1039/b716517j


  • eng

Conference Location

  • England