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Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma.

Publication ,  Journal Article
Palmer, J; Goggins, T; Broadwater, G; Chao, N; Horwitz, M; Beaven, A; Sullivan, K; Coleman, RE; Rizzieri, D
Published in: Bone Marrow Transplant
June 2011

Positron emission tomography (PET) in conjunction with computed tomography is a frequently used modality for staging patients with lymphoma. Utility of PET-computed tomography before or early following auto-SCT has not been as rigorously evaluated. We retrospectively analyzed patients who received auto-SCT for treatment of relapsed or refractory non-Hodgkins lymphoma or Hodgkins disease between the years of 1996 and 2007. Patients who had either a PET scan following salvage chemotherapy within 14 weeks of transplantation (pre-PET), and/or a PET scan 6-14 weeks following transplantation (post-PET) were included. A total of 90 patients were identified for analysis. The median follow-up time is 3.3 years, with a range of 0.13-12.0 years. The median PFS was 4.6 years, and median OS was 5.1 years. At the time of this analysis, 34 patients (37%) experienced disease relapse, and 25 (27%) of the patients died from disease progression. In multivariate Cox proportional hazards analysis, post-PET did not predict for outcome, pre-PET positivity predicted for decrease in PFS. In conclusion, post-PET scan did not predict for PFS or OS in multivariate analysis. Positive pre-PET scan did predict for PFS as seen in previous studies, and may help identify patients who would benefit from innovative post transplant therapies.

Duke Scholars

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

June 2011

Volume

46

Issue

6

Start / End Page

847 / 851

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Transplantation, Autologous
  • Time Factors
  • Retrospective Studies
  • Prognosis
  • Predictive Value of Tests
  • Positron-Emission Tomography
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Palmer, J., Goggins, T., Broadwater, G., Chao, N., Horwitz, M., Beaven, A., … Rizzieri, D. (2011). Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma. Bone Marrow Transplant, 46(6), 847–851. https://doi.org/10.1038/bmt.2010.203
Palmer, J., T. Goggins, G. Broadwater, N. Chao, M. Horwitz, A. Beaven, K. Sullivan, R. E. Coleman, and D. Rizzieri. “Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma.Bone Marrow Transplant 46, no. 6 (June 2011): 847–51. https://doi.org/10.1038/bmt.2010.203.
Palmer J, Goggins T, Broadwater G, Chao N, Horwitz M, Beaven A, et al. Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma. Bone Marrow Transplant. 2011 Jun;46(6):847–51.
Palmer, J., et al. “Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma.Bone Marrow Transplant, vol. 46, no. 6, June 2011, pp. 847–51. Pubmed, doi:10.1038/bmt.2010.203.
Palmer J, Goggins T, Broadwater G, Chao N, Horwitz M, Beaven A, Sullivan K, Coleman RE, Rizzieri D. Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma. Bone Marrow Transplant. 2011 Jun;46(6):847–851.

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

June 2011

Volume

46

Issue

6

Start / End Page

847 / 851

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Transplantation, Autologous
  • Time Factors
  • Retrospective Studies
  • Prognosis
  • Predictive Value of Tests
  • Positron-Emission Tomography
  • Middle Aged
  • Male