Radiotherapy dose-response analysis for diffuse large B-cell lymphoma with a complete response to chemotherapy.

Published online

Journal Article

OBJECTIVE: To examine the efficacy of different radiation doses after achievement of a complete response to chemotherapy in diffuse large B-cell lymphoma (DLBCL). METHODS: Patients with stage I-IV DLBCL treated from 1995-2009 at Duke Cancer Institute who achieved a complete response to chemotherapy were reviewed. In-field control, event-free survival, and overall survival were calculated using the Kaplan-Meier method. Dose response was evaluated by grouping treated sites by delivered radiation dose. RESULTS: 105 patients were treated with RT to 214 disease sites. Chemotherapy (median 6 cycles) was R-CHOP (65%), CHOP (26%), R-CNOP (2%), or other (7%). Post-chemotherapy imaging was PET/CT (88%), gallium with CT (1%), or CT only (11%). The median RT dose was 30 Gy (range, 12-40 Gy). The median radiation dose was higher for patients with stage I-II disease compared with patients with stage III-IV disease (30 versus 24.5 Gy, p < 0.001). Five-year in-field control, event-free survival, and overall survival for all patients was 94% (95% CI: 89-99%), 84% (95% CI: 77-92%), and 91% (95% CI: 85-97%), respectively. Six patients developed an in-field recurrence at 10 sites, without a clear dose response. In-field failure was higher at sites ≥ 10 cm (14% versus 4%, p = 0.06). CONCLUSION: In-field control was excellent with a combined modality approach when a complete response was achieved after chemotherapy without a clear radiation dose response.

Full Text

Duke Authors

Cited Authors

  • Dorth, JA; Prosnitz, LR; Broadwater, G; Beaven, AW; Kelsey, CR

Published Date

  • June 21, 2012

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 100 -

PubMed ID

  • 22720801

Pubmed Central ID

  • 22720801

Electronic International Standard Serial Number (EISSN)

  • 1748-717X

Digital Object Identifier (DOI)

  • 10.1186/1748-717X-7-100

Language

  • eng

Conference Location

  • England