A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation.

Journal Article (Journal Article;Review)

Oral anticoagulation with vitamin K antagonists has served as the primary treatment for the prevention of stroke and systemic embolization in patients with atrial fibrillation (AF) for decades. Over the past several years, multiple novel oral anticoagulants targeting key mediators of coagulation, including thrombin and factor Xa, have been developed. Specifically, agents targeting thrombin (dabigatran) and factor Xa (apixaban and rivaroxaban) have either reached late stages of clinical development (apixaban) or have received approval (dabigatran, rivaroxaban) by the US Food and Drug Administration for use in patients with nonvalvular AF. The promising results derived from large-scale clinical trials with these agents compared to warfarin expand the available therapeutic options for the prevention of stroke and systemic embolization in this rapidly increasing patient population. Here we present a general guidance pathway for the initiation and selection of oral anticoagulants in patients with AF.

Full Text

Duke Authors

Cited Authors

  • Wisler, JW; Becker, RC

Published Date

  • June 2012

Published In

Volume / Issue

  • 11 / 2

Start / End Page

  • 55 - 61

PubMed ID

  • 22595815

Electronic International Standard Serial Number (EISSN)

  • 1535-2811

Digital Object Identifier (DOI)

  • 10.1097/HPC.0b013e31825298ef


  • eng

Conference Location

  • United States