Factor IXa as a target for pharmacologic inhibition in acute coronary syndrome.

Journal Article (Journal Article;Review)

Anticoagulant therapy, combined with platelet-directed inhibitors, represents a standard-of-care in the management of patients with acute coronary syndrome, particularly those who require percutaneous coronary interventions. While a vast clinical experience, coupled with large clinical trials have collectively provided guidance, an optimal anticoagulant drug and applied strategy, defined as one that reduces thrombotic and hemorrhagic events consistently, with minimal off-target effects and active control of systemic anticoagulation according to patient and clinical-setting specific need, remains at large. An advancing knowledge of coagulation, hemostasis, and thrombosis suggests that factor IXa, a protease that governs thrombin generation in common thrombotic disorders may represent a prime target for pharmacologic inhibition.

Full Text

Duke Authors

Cited Authors

  • Roser-Jones, C; Chan, M; Howard, EL; Becker, KCD; Rusconi, CP; Becker, RC

Published Date

  • August 2011

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • e22 - e35

PubMed ID

  • 21749674

Electronic International Standard Serial Number (EISSN)

  • 1755-5922

Digital Object Identifier (DOI)

  • 10.1111/j.1755-5922.2010.00134.x


  • eng

Conference Location

  • England