Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.

Published

Journal Article (Review)

Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.

Full Text

Duke Authors

Cited Authors

  • Williams, MS; Weiss, EJ; Sabatine, MS; Simon, DI; Bahou, WF; Becker, LC; Parise, LV; Dauerman, HL; French, PA; Smyth, SS; Becker, RC; 2010 Platelet Colloquium Participants,

Published Date

  • December 2010

Published In

Volume / Issue

  • 30 / 12

Start / End Page

  • 2372 - 2384

PubMed ID

  • 21084706

Pubmed Central ID

  • 21084706

Electronic International Standard Serial Number (EISSN)

  • 1524-4636

International Standard Serial Number (ISSN)

  • 1079-5642

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.110.218131

Language

  • eng