Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.
Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.
Duke Scholars
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Related Subject Headings
- Polymorphism, Genetic
- Platelet Membrane Glycoproteins
- Platelet Aggregation Inhibitors
- Phenotype
- Humans
- Genotype
- Genome-Wide Association Study
- Gene Expression Regulation
- Gene Expression Profiling
- Drug Resistance
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Polymorphism, Genetic
- Platelet Membrane Glycoproteins
- Platelet Aggregation Inhibitors
- Phenotype
- Humans
- Genotype
- Genome-Wide Association Study
- Gene Expression Regulation
- Gene Expression Profiling
- Drug Resistance