Antithrombotic therapy in acute coronary syndrome: how far up the coagulation cascade will we go?

Journal Article (Journal Article;Review)

The contribution of thrombosis to the natural history and clinical expression of advanced atherosclerotic coronary artery disease is well established. Less well understood is the biochemical and pathobiological distinction between normal hemostasis and thrombosis as the proximate cause of acute coronary syndrome. In this article, we summarize an evolving area of interest within the field of antithrombotic therapy--the contact system and the intrinsic pathway of coagulation, focusing our discussion on factors XI, XII, and IX to include their biochemical properties, relationship to arterial thrombosis phenotypes, and rational for future investigation of targeted pharmacotherapy.

Full Text

Duke Authors

Cited Authors

  • Woodruff, B; Sullenger, B; Becker, RC

Published Date

  • July 2010

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 315 - 320

PubMed ID

  • 20432072

Electronic International Standard Serial Number (EISSN)

  • 1534-3170

Digital Object Identifier (DOI)

  • 10.1007/s11886-010-0117-6


  • eng

Conference Location

  • United States