Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics.


Journal Article (Review)

Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

Full Text

Duke Authors

Cited Authors

  • Becker, RC; Povsic, T; Cohen, MG; Rusconi, CP; Sullenger, B

Published Date

  • March 2010

Published In

  • Thromb Haemost

Volume / Issue

  • 103 / 3

Start / End Page

  • 586 - 595

PubMed ID

  • 20135076

Pubmed Central ID

  • 20135076

Electronic International Standard Serial Number (EISSN)

  • 2567-689X

Digital Object Identifier (DOI)

  • 10.1160/TH09-10-0716


  • eng

Conference Location

  • Germany