Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics.

Journal Article (Journal Article;Review)

Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

Full Text

Duke Authors

Cited Authors

  • Becker, RC; Povsic, T; Cohen, MG; Rusconi, CP; Sullenger, B

Published Date

  • March 2010

Published In

  • Thromb Haemost

Volume / Issue

  • 103 / 3

Start / End Page

  • 586 - 595

PubMed ID

  • 20135076

Electronic International Standard Serial Number (EISSN)

  • 2567-689X

Digital Object Identifier (DOI)

  • 10.1160/TH09-10-0716

Language

  • eng

Conference Location

  • Germany