Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics.
Journal Article (Journal Article;Review)
Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.
Full Text
Duke Authors
Cited Authors
- Becker, RC; Povsic, T; Cohen, MG; Rusconi, CP; Sullenger, B
Published Date
- March 2010
Published In
- Thromb Haemost
Volume / Issue
- 103 / 3
Start / End Page
- 586 - 595
PubMed ID
- 20135076
Electronic International Standard Serial Number (EISSN)
- 2567-689X
Digital Object Identifier (DOI)
- 10.1160/TH09-10-0716
Language
- eng
Conference Location
- Germany