Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics.
Publication
, Journal Article
Becker, RC; Povsic, T; Cohen, MG; Rusconi, CP; Sullenger, B
Published in: Thromb Haemost
March 2010
Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.
Duke Scholars
Published In
Thromb Haemost
DOI
EISSN
2567-689X
Publication Date
March 2010
Volume
103
Issue
3
Start / End Page
586 / 595
Location
Germany
Related Subject Headings
- SELEX Aptamer Technique
- Humans
- Fibrinolytic Agents
- Cardiovascular System & Hematology
- Blood Coagulation Factors
- Aptamers, Nucleotide
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Becker, R. C., Povsic, T., Cohen, M. G., Rusconi, C. P., & Sullenger, B. (2010). Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics. Thromb Haemost, 103(3), 586–595. https://doi.org/10.1160/TH09-10-0716
Becker, Richard C., Thomas Povsic, Mauricio G. Cohen, Christopher P. Rusconi, and Bruce Sullenger. “Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics.” Thromb Haemost 103, no. 3 (March 2010): 586–95. https://doi.org/10.1160/TH09-10-0716.
Becker RC, Povsic T, Cohen MG, Rusconi CP, Sullenger B. Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics. Thromb Haemost. 2010 Mar;103(3):586–95.
Becker, Richard C., et al. “Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics.” Thromb Haemost, vol. 103, no. 3, Mar. 2010, pp. 586–95. Pubmed, doi:10.1160/TH09-10-0716.
Becker RC, Povsic T, Cohen MG, Rusconi CP, Sullenger B. Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics. Thromb Haemost. 2010 Mar;103(3):586–595.
Published In
Thromb Haemost
DOI
EISSN
2567-689X
Publication Date
March 2010
Volume
103
Issue
3
Start / End Page
586 / 595
Location
Germany
Related Subject Headings
- SELEX Aptamer Technique
- Humans
- Fibrinolytic Agents
- Cardiovascular System & Hematology
- Blood Coagulation Factors
- Aptamers, Nucleotide
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology