Antidote-controlled antithrombotic therapy targeting factor IXa and von Willebrand factor.

Journal Article

Thrombotic disorders and their common clinical phenotypes of acute myocardial infarction, ischemic stroke, and venous thromboembolism are the proximate cause of substantial morbidity, mortality, and health care expenditures worldwide. Accordingly, therapies designed to attenuate thrombus initiation and propagation, reflecting integrated platelet-mediated and coagulation protease-mediated events, respectively, represent a standard of care. Unfortunately, there are numerous inherent limitations of existing therapies that include target nonselectivity, variable onset and offset of pharmacodynamic effects, a narrow efficacy-safety profile, and the absence of a safe and reliable platform for either accurate titration, based on existing patient-specific, disease-specific, and clinical conditions, or active reversibility. Herein, we summarize our experience with oligonucleotide antithrombotic agents and their complementary antidotes, targeting the platelet adhesive protein von Willebrand factor and the pivotal coagulation protease factor IXa.

Full Text

Duke Authors

Cited Authors

  • Becker, RC; Oney, S; Becker, KCD; Sullenger, B

Published Date

  • September 2009

Published In

Volume / Issue

  • 1175 /

Start / End Page

  • 61 - 70

PubMed ID

  • 19796078

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2009.05017.x

Language

  • eng

Conference Location

  • United States