G-protein-coupled receptors as signaling targets for antiplatelet therapy.

Published

Journal Article (Review)

Platelet G protein-coupled receptors (GPCRs) initiate and reinforce platelet activation and thrombus formation. The clinical utility of antagonists of the P2Y(12) receptor for ADP suggests that other GPCRs and their intracellular signaling pathways may represent viable targets for novel antiplatelet agents. For example, thrombin stimulation of platelets is mediated by 2 protease-activated receptors (PARs), PAR-1 and PAR-4. Signaling downstream of PAR-1 or PAR-4 activates phospholipase C and protein kinase C and causes autoamplification by production of thromboxane A(2), release of ADP, and generation of more thrombin. In addition to ADP receptors, thrombin and thromboxane A(2) receptors and their downstream effectors-including phosphoinositol-3 kinase, Rap1b, talin, and kindlin-are promising targets for new antiplatelet agents. The mechanistic rationale and available clinical data for drugs targeting disruption of these signaling pathways are discussed. The identification and development of new agents directed against specific platelet signaling pathways may offer an advantage in preventing thrombotic events while minimizing bleeding risk.

Full Text

Duke Authors

Cited Authors

  • Smyth, SS; Woulfe, DS; Weitz, JI; Gachet, C; Conley, PB; Goodman, SG; Roe, MT; Kuliopulos, A; Moliterno, DJ; French, PA; Steinhubl, SR; Becker, RC; 2008 Platelet Colloquium Participants,

Published Date

  • April 2009

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 449 - 457

PubMed ID

  • 19023091

Pubmed Central ID

  • 19023091

Electronic International Standard Serial Number (EISSN)

  • 1524-4636

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.108.176388

Language

  • eng

Conference Location

  • United States