Choice of agents to limit the coagulation cascade in acute coronary syndromes

Journal Article

Arterial thrombosis, the predominant event in acute coronary syndromes (ACS), is the end-result of endothelial cell dysfunction, impaired vascular thromboresistance, and sudden atheromatous plaque disruption, each occurring amid a backdrop of inflammation and inflammatory mediators. Because the contribution of individual coagulation proteins to coronary arterial thrombosis varies from modest to marked, selective pharmacologic targeting is both pathobiologically sound and clinically preferred. The development of secondgeneration anticoagulants with broadened therapeutic windows represents an advance in the management of ACS. Copyright © 2002 by Current Science Inc.

Full Text

Duke Authors

Cited Authors

  • Becker, RC

Published Date

  • 2002

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 272 - 277

International Standard Serial Number (ISSN)

  • 1523-3782

Digital Object Identifier (DOI)

  • 10.1007/s11886-002-0062-0