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Thrombin: Structure, biochemistry, measurement, and status in clinical medicine

Publication ,  Journal Article
Becker, RC; Spencer, FA
Published in: Journal of Thrombosis and Thrombolysis
1998

Thrombin remains a molecule of great interest to scientists and clinicians alike because of its important role in hemostasis, thrombosis, inflammation and vascular remodeling. Yet one of the great challenges has been the inhibition of thrombin generation to a degree that minimizes intravascular thrombosis while preserving physiologic hemostasis. It has become increasingly clear that high levels of anticoagulation with either direct or indirect thrombin antagonists are not beneficial and, in fact, are quite detrimental. Despite the overwhelming shift of interest toward the platelet in clinical trials of acute coronary syndromes, much can be gained through further investigation of coagulation processes responsible for thrombin generation and activity.

Duke Scholars

Published In

Journal of Thrombosis and Thrombolysis

DOI

Publication Date

1998

Volume

5

Issue

3

Start / End Page

215 / 229

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Becker, R. C., & Spencer, F. A. (1998). Thrombin: Structure, biochemistry, measurement, and status in clinical medicine. Journal of Thrombosis and Thrombolysis, 5(3), 215–229. https://doi.org/10.1023/A:1008843925851
Becker, R. C., and F. A. Spencer. “Thrombin: Structure, biochemistry, measurement, and status in clinical medicine.” Journal of Thrombosis and Thrombolysis 5, no. 3 (1998): 215–29. https://doi.org/10.1023/A:1008843925851.
Becker RC, Spencer FA. Thrombin: Structure, biochemistry, measurement, and status in clinical medicine. Journal of Thrombosis and Thrombolysis. 1998;5(3):215–29.
Becker, R. C., and F. A. Spencer. “Thrombin: Structure, biochemistry, measurement, and status in clinical medicine.” Journal of Thrombosis and Thrombolysis, vol. 5, no. 3, 1998, pp. 215–29. Scival, doi:10.1023/A:1008843925851.
Becker RC, Spencer FA. Thrombin: Structure, biochemistry, measurement, and status in clinical medicine. Journal of Thrombosis and Thrombolysis. 1998;5(3):215–229.

Published In

Journal of Thrombosis and Thrombolysis

DOI

Publication Date

1998

Volume

5

Issue

3

Start / End Page

215 / 229

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1103 Clinical Sciences