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Thrombin antagonists and antiplatelet agents

Publication ,  Journal Article
Becker, RC
Published in: The American Journal of Cardiology
1992

The clinical benefits of thrombolytic therapy for the treatment of myocardial infarction are recognized widely. However, 2 major limiting factors have become evident: (1)20-25% of coronary arterial thrombi are resistant to lysis; and (2) coronary reocclusion occurs In 10-15% of patients. There is increasing evidence that both phenomena are caused by heightened procoagulant activity localized primarily at the site of atheromatous plaque rupture. Thrombin, the pivotal enzyme in all coagulation processes, is activated, stimulating fibrin formation and platelet aggregation. Platelet activation, by thrombinand nonthrombin-mediated mechanisms, occurs as well, further increasing thrombotic tendency. Thus, a potent and well-localized procoagulant state may be continuously amplified, increasing both during and frequently after thrombolytic therapy. Current treatment strategies are designed to enhance fibrinolytic and anticoagulant activity, while neutralizing the expression of procoagulant factors. Thrombin antagonism and platelet inhibition, primarily with heparin and aspirin, respectively, form the mainstay of conjunctive therapy. Their benefits have been recognized, decreasing thromboembolic events and patient mortality. However, intrinsic limitations suggest that more potent and selective agents will be required to overcome effectively the problems of thrombolytic resistance and coronary reocclusion. In experimental models, specific thrombin antagonists and antiplatelet agents have shown superiority over heparin and aspirin. Further investigation to define the overall safety and efficacy profile of these newer agents will be required, however, prior to their widescale implementation in clinical practice. © 1991.

Duke Scholars

Published In

The American Journal of Cardiology

ISSN

0002-9149

Publication Date

1992

Volume

69

Issue

2

Start / End Page

A39 / A51

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Becker, R. C. (1992). Thrombin antagonists and antiplatelet agents. The American Journal of Cardiology, 69(2), A39–A51.
Becker, R. C. “Thrombin antagonists and antiplatelet agents.” The American Journal of Cardiology 69, no. 2 (1992): A39–51.
Becker RC. Thrombin antagonists and antiplatelet agents. The American Journal of Cardiology. 1992;69(2):A39–51.
Becker, R. C. “Thrombin antagonists and antiplatelet agents.” The American Journal of Cardiology, vol. 69, no. 2, 1992, pp. A39–51.
Becker RC. Thrombin antagonists and antiplatelet agents. The American Journal of Cardiology. 1992;69(2):A39–A51.
Journal cover image

Published In

The American Journal of Cardiology

ISSN

0002-9149

Publication Date

1992

Volume

69

Issue

2

Start / End Page

A39 / A51

Related Subject Headings

  • Cardiovascular System & Hematology
  • 1102 Cardiorespiratory Medicine and Haematology