Seminars in thrombosis, thrombolysis and vascular biology. 3. Platelet activity in cardiovascular disease
Platelets contribute to normal hemostasis by adhering to subendothelial tissues after vascular damage has taken place and then recruiting additional platelets through the process of aggregation. Activation of the coagulation cascade ultimately results in fibrin deposition. In pathological conditions, thrombogenic surfaces act as a nidus for platelet adherence and thrombus formation. The ability of platelet-inhibiting agents to prevent or impair platelet-mediated thrombotic and thromboembolic events is of vital importance in the prevention and treatment of cardiovascular diseases, including myocardial infarction, unstable angina and stroke. They also serve as important adjuvants following percutaneous transluminal coronary angioplasty and saphenous vein bypass grafting. Future investigations will likely uncover additional indications.
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- Cardiovascular System & Hematology
- 1102 Cardiorespiratory Medicine and Haematology
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Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Cardiovascular System & Hematology
- 1102 Cardiorespiratory Medicine and Haematology