Diaphragm pacing in amyotrophic lateral sclerosis: a literature review.

Journal Article (Journal Article;Review)

Amyotrophic lateral sclerosis (ALS) remains a rapidly progressive fatal degenerative disease of motor neurons for which there are few interventions to slow disease progression or improve quality of life. A diaphragm pacing system was approved by the U.S. Food and Drug Administration in September 2011 for ALS under a Humanitarian Device Exemption. News of this approval has been met with a combination of excitement and uncertainty by members of the ALS community. We review the currently available data on the diaphragm pacing system and its use in ALS. Diaphragm pacing appears to be reasonably safe in carefully selected patients, but flaws in the reporting on it thus far preclude conclusions regarding efficacy. Further study is needed.

Full Text

Duke Authors

Cited Authors

  • Scherer, K; Bedlack, RS

Published Date

  • July 2012

Published In

Volume / Issue

  • 46 / 1

Start / End Page

  • 1 - 8

PubMed ID

  • 22692995

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.23419


  • eng

Conference Location

  • United States