Cis- and trans-acting ribozymes from a human pathogen, hepatitis delta virus.

Journal Article (Journal Article;Review)

Hepatitis delta virus (HDV) contains two self-cleaving RNA sequences (ribozymes) that may naturally function as such in human cells. A pseudo-knot-containing structural motif, which is distinct from the well-characterized secondary structures of self-cleaving RNAs common to the plant pathogenic RNAs, is shared by the cis-acting HDV ribozymes. Definition of the sequences and secondary structures of the HDV ribozymes has facilitated the design of novel catalytic molecules, such as small RNA circles, capable of site-specific cleavage of RNA in trans.

Full Text

Duke Authors

Cited Authors

  • Been, MD

Published Date

  • June 1, 1994

Published In

Volume / Issue

  • 19 / 6

Start / End Page

  • 251 - 256

PubMed ID

  • 8073503

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/0968-0004(94)90151-1


  • eng

Conference Location

  • England